PSMC5 Antibody, FITC conjugated

1. autoinflammation-associated H443P nlrc4 mutant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-8-mediated cell death dependent on FADD but independent of Ser(533) phosphorylation. PMID: 27974463
2. Our data suggest that PSMC5 facilitates the damaging effects of radiation in radiation-responsive H460 cancer cells and therefore may serve as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients. PMID: 26592665
3. XopJ has protease activity to specifically degrade RPT6. PMID: 25739698
4. TRIP-1 regulates fibroblast acquisition of phenotype and function associated with myofibroblasts. PMID: 24528651
5. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity PMID: 24482233
6. Rpt6 interacts directly with CKIP-1 and promotes the turnover of Smurf1. PMID: 23032291
7. Sug1 plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO. PMID: 22771340
8. Findings show that Sug1 is crucial for regulating histone H3K4me3 and H3R17me2 at the cytokine inducible MHC-II and CIITA promoters. PMID: 19660582
9. SUG1 has a role in ubiquitin/proteasome-mediated degradation of estrogen receptors PMID: 14702340
10. Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo. PMID: 16499872
11. p45 plays an important role in regulating ataxin-3 degradation by the proteasome. PMID: 17302910
12. These data demonstrate that both 19S and 20S subunits of the 26S proteasome play specific and critical roles in regulating CIITA activity and MHC class II transcription. PMID: 18215421
13. The current study strongly implicates the 19S ATPase Sug1 in modifying histones to initiate major histocompatibility complex class II transcription and provides novel insights into the role of the proteasome in the regulation of mammalian transcription. PMID: 18662994
14. SUG-1 has a unique role in linking the transcription and degradation processes via its ability to interact with SRC-3. PMID: 19144644

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HGNC: 9552

OMIM: 601681

KEGG: hsa:5705

STRING: 9606.ENSP00000310572

UniGene: Hs.79387